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By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. In vitro studies of cytochrome P450 isoenzymes using human liver microsomes indicate that neither tizanidine nor the major metabolites are likely to affect the metabolism of other drugs metabolized by cytochrome P450 isoenzymes. AB Products meeting necessary bioequivalence requirements. Cheapest zanaflex from a pharmacy Part of the problem with pain from the sciatica can be due to muscle spasms. Zanaflex is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity. You may take Zanaflex with or without food, but take it the same way each time. 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